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Glucose Autoxidation Induces Functional Damage to Proteins via Modification of Critical Arginine Residues()

Non-enzymatic modification of proteins in hyperglycemia is a major mechanism causing diabetic complications. These modifications can have pathogenic consequences when they target active site residues, thus affecting protein function. In the present study, we examined the role of glucose autoxidation...

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Detalhes bibliográficos
Main Authors: Chetyrkin, Sergei, Mathis, Missy, Pedchenko, Vadim, Sanchez, Otto A., McDonald, W. Hayes, Hachey, David L., Madu, Hartman, Stec, Donald, Hudson, Billy, Voziyan, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140462/
https://ncbi.nlm.nih.gov/pubmed/21661747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200757d
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