Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self antigens in cancer patients

PURPOSE: The use of tumor-derived proteins as cancer vaccines is complicated by tolerance to these self antigens. Tolerance may be broken by immunization with activated, autologous, ex vivo generated and antigen-loaded, antigen-presenting cells (APC); however, targeting tumor antigen directly to APC...

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Main Authors: Morse, Michael A., Chapman, Robert, Powderly, John, Blackwell, Kimberly, Keler, Tibor, Green, Jennifer, Riggs, Renee, He, Li-Zhen, Ramakrishna, Venky, Vitale, Laura, Zhao, Biwei, Butler, Stephen A., Hobeika, Amy, Osada, Takuya, Davis, Thomas, Clay, Timothy, Lyerly, H. Kim
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139834/
https://ncbi.nlm.nih.gov/pubmed/21632857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0891
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