Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

CD4(+)CD25(high)FoxP3(+) regulatory T (Treg) cells limit antigen-specific immune responses and are a cause of suppressed anticancer immunity. In preclinical and clinical studies, we assessed the immune consequences of FoxP3(+) Treg-cell depletion in patients with advanced malignancies. We demonstrat...

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Detalhes bibliográficos
Main Authors: Morse, Michael A., Hobeika, Amy C., Osada, Takuya, Serra, Delila, Niedzwiecki, Donna, Lyerly, H. Kim, Clay, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481547/
https://ncbi.nlm.nih.gov/pubmed/18519811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-135319
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