Molecular and Functional Characteristics of Ovarian Surface Epithelial Cells Transformed by KrasG12D and loss of Pten in a Mouse Model in vivo

Ovarian cancer is a complex and deadly disease that remains difficult to detect at an early curable stage. Furthermore, although some oncogenic (Kras, Pten/PI3K and Trp53) pathways that are frequently mutated, deleted or amplified in ovarian cancer are known, how these pathways initiate and drive sp...

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Detalhes bibliográficos
Main Authors: Mullany, Lisa K., Fan, Heng-Yu, Liu, Zhilin, White, Lisa D., Marshall, Alexandra, Gunaratne, Preethi, Anderson, Matthew L., Creighton, Chad J., Xin, Li, Deavers, Michael, Wong, Kwong-Kwok, Richards, JoAnne S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139785/
https://ncbi.nlm.nih.gov/pubmed/21423204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.70
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