Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapy

PURPOSE: Clinical trials on adoptive T-cell therapy (ACT) using expanded tumor-infiltrating lymphocytes (TIL) have shown response rates of over 50% in refractory melanoma. However, little is known how clinical and pathologic features impact TIL outgrowth isolated from metastatic melanoma tumors. EXP...

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Main Authors: Joseph, Richard W., Peddareddigari, Vijay R., Liu, Ping, Miller, Priscilla W., Overwijk, Willem W., Bekele, Nebiyou B., Ross, Merrick I., Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Prieto, Victor G., McMannis, John D., Papadopoulos, Nicholas, Kim, Kevin, Homsi, Jade, Bedikian, Agop, Hwu, Wen-Jen, Hwu, Patrick, Radvanyi, Laszlo G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139726/
https://ncbi.nlm.nih.gov/pubmed/21632855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2769
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