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Benzisothiazolones as modulators of macrophage migration inhibitory factor

Substituted N-phenylbenzisothiazolones have been investigated as inhibitors of the tautomerase activity of the proinflammatory cytokine MIF (macrophage migration inhibitory factor). Numerous compounds were found to possess antagonist activity in the low micromolar range with the most potent being th...

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Hlavní autoři: Jorgensen, William L., Trofimov, Alexander, Du, Xin, Hare, Alissa A., Leng, Lin, Bucala, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139435/
https://ncbi.nlm.nih.gov/pubmed/21719283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.127
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