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Benzisothiazolones as modulators of macrophage migration inhibitory factor

Substituted N-phenylbenzisothiazolones have been investigated as inhibitors of the tautomerase activity of the proinflammatory cytokine MIF (macrophage migration inhibitory factor). Numerous compounds were found to possess antagonist activity in the low micromolar range with the most potent being th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jorgensen, William L., Trofimov, Alexander, Du, Xin, Hare, Alissa A., Leng, Lin, Bucala, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139435/
https://ncbi.nlm.nih.gov/pubmed/21719283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.127
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