CCI-779 Inhibits Cell-Cycle G2/M Progression and Invasion of Castration Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability

The cell-cycle G2/M phase gene UBE2C is over-expressed in various solid tumors including castration-resistant prostate cancer (CRPC). Our recent studies found UBE2C to be a CRPC-specific androgen receptor (AR) target gene that is necessary for CRPC growth, providing a potential novel target for ther...

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Autori principali: Wang, Hongyan, Zhang, Chunpeng, Rorick, Anna, Wu, Dayong, Chiu, Ming, Thomas-Ahner, Jennifer, Chen, Zhong, Chen, Hongyan, Clinton, Steven K., Chan, Kenneth K., Wang, Qianben
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138908/
https://ncbi.nlm.nih.gov/pubmed/21593191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4576
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