Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

BACKGROUND: Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. T...

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Bibliografiske detaljer
Main Authors: Akbar, Huzoor, Shang, Xun, Perveen, Rehana, Berryman, Mark, Funk, Kevin, Johnson, James F., Tandon, Narendra N., Zheng, Yi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138762/
https://ncbi.nlm.nih.gov/pubmed/21789221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022117
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