Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate platelet activation and thrombus formation. We investigated the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Duan, Xin, Perveen, Rehana, Dandamudi, Akhila, Adili, Reheman, Johnson, James, Funk, Kevin, Berryman, Mark, Davis, Ashley Kuenzi, Holinstat, Michael, Zheng, Yi, Akbar, Huzoor
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222210/
https://ncbi.nlm.nih.gov/pubmed/34162972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92654-6
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