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Phospholipase Cζ binding to PtdIns(4,5)P(2) requires the XY-linker region
Phospholipase C-zeta (PLCζ) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca(2+) oscillations required for egg activation at fertilization. PLCζ lacks a PH domain, which targets PLCδ1 to the phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) substrate in the pla...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Company of Biologists
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138701/ https://ncbi.nlm.nih.gov/pubmed/21730019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.083485 |
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