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Pleiotropic and Age-dependent Effects of Decreased Protein Modification by O-Linked N-Acetylglucosamine on Pancreatic β-Cell Function and Vascularization

The hexosamine biosynthesis pathway (HBP) regulates the post-translational modification of nuclear and cytoplasmic protein by O-linked N-acetylglucosamine (O-GlcNAc). Numerous studies have demonstrated increased flux through this pathway contributes to the development of β-cell dysfunction. The effe...

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Autori principali: Soesanto, Yudi, Luo, Bai, Parker, Glendon, Jones, Deborah, Cooksey, Robert C., McClain, Donald A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138322/
https://ncbi.nlm.nih.gov/pubmed/21622566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249508
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