Retinal O-linked N-acetylglucosamine protein modifications: implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy

PURPOSE: Hyperglycemia activates several metabolic pathways, including the hexosamine biosynthetic pathway. Uridine diphosphate N-acetylglucosamine (GlcNAc) is the product of the hexosamine biosynthetic pathway and the substrate for O-linked GlcNAc (O-GlcNAc) modification. This modification affects...

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Main Authors: Gurel, Zafer, Sieg, Kelsey M., Shallow, Keegan D., Sorenson, Christine M., Sheibani, Nader
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668662/
https://ncbi.nlm.nih.gov/pubmed/23734074
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