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Protein Modification by O-linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells

OBJECTIVE: Glucose flux through the hexosamine biosynthesis pathway (HBP) has been implicated in the development of diabetic vascular complications. O-linked N-acetylglucosamine (O-GlcNAc) modification on protein is the major mechanism mediating the actions of the HBP. Impaired angiogenesis is well-...

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Bibliografiske detaljer
Main Authors: Luo, Bai, Soesanto, Yudi, McClain, Donald A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734484/
https://ncbi.nlm.nih.gov/pubmed/18174452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.107.159533
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