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Protein Modification by O-linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells
OBJECTIVE: Glucose flux through the hexosamine biosynthesis pathway (HBP) has been implicated in the development of diabetic vascular complications. O-linked N-acetylglucosamine (O-GlcNAc) modification on protein is the major mechanism mediating the actions of the HBP. Impaired angiogenesis is well-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734484/ https://ncbi.nlm.nih.gov/pubmed/18174452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.107.159533 |
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