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Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency

The hypothalamic melanocortin system is unique among neuropeptide systems controlling energy homeostasis, in that both anorexigenic proopiomelanocortin (POMC)-derived and orexigenic Agouti related-peptide (AgRP)-derived ligands act at the same receptors, namely melanocortin 3 and 4 receptors (MC3/4R...

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Autores principales: Corander, Marcus P., Rimmington, Debra, Challis, Benjamin G., O'Rahilly, Stephen, Coll, Anthony P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137464/
https://ncbi.nlm.nih.gov/pubmed/21363936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-1450
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