Peripheral administration of the N-terminal POMC fragment 1-28 to Pomc(−/−) mice reduces food intake and weight but does not affect adrenal growth or corticosterone production

Pro-opiomelanocortin (POMC) is a polypeptide precursor that undergoes extensive processing to yield a range of peptides with biologically diverse functions. POMC-derived ACTH is vital for normal adrenal function and the melanocortin α-MSH plays a key role in appetite control and energy homeostasis....

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Main Authors: Coll, Anthony P., Fassnacht, Martin, Klammer, Steffen, Hahner, Stephanie, Schulte, Dominik M., Piper, Sarah, Tung, YC Loraine, Challis, Benjamin G., Weinstein, Yacob, Allolio, Bruno, O'Rahilly, Stephen, Beuschlein, Felix
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638022/
https://ncbi.nlm.nih.gov/pubmed/16899584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/joe.1.06749
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