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Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids
[Image: see text] Unnatural amino acids (Uaas) can be translationally incorporated into proteins in vivo using evolved tRNA/aminoacyl-tRNA synthetase (RS) pairs, affording chemistries inaccessible when restricted to the 20 natural amino acids. To date, most evolved RSs aminoacylate Uaas chemically s...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical Society
2011
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137230/ https://ncbi.nlm.nih.gov/pubmed/21545173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200057a |
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