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Enriching targeted sequencing experiments for rare disease alleles

Motivation: Next-generation targeted resequencing of genome-wide association study (GWAS)-associated genomic regions is a common approach for follow-up of indirect association of common alleles. However, it is prohibitively expensive to sequence all the samples from a well-powered GWAS study with su...

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Autori principali: Edwards, Todd L., Song, Zhuo, Li, Chun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137214/
https://ncbi.nlm.nih.gov/pubmed/21700677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btr324
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