Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine.
Pertussis toxin (PT) is an important protective antigen in vaccines against whooping cough, and a genetically detoxified PT analog is the preferred form of the immunogen. Several amino acids of the S1 subunit were identified as functionally critical residues by site-directed mutagenesis, specificall...
محفوظ في:
| الحاوية / القاعدة: | Infect Immun |
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| المؤلفون الرئيسيون: | , , , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
American Society for Microbiology (ASM)
1990
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2228237/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.11.3653-3662.1990 |
| الوسوم: |
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