Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.

Nontoxic analogs of pertussis toxin (PT), produced by in vitro mutagenesis of the tox operon, are immunogenic and protective against infection by Bordetella pertussis. The moderate levels of PT production by B. pertussis, however, make it the limiting antigen in the formulation of multicomponent, ac...

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Bibliographic Details
Main Authors: Zealey, G R, Loosmore, S M, Yacoob, R K, Cockle, S A, Herbert, A B, Miller, L D, Mackay, N J, Klein, M H
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC195193/
https://ncbi.nlm.nih.gov/pubmed/1539974
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