Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.

Nontoxic analogs of pertussis toxin (PT), produced by in vitro mutagenesis of the tox operon, are immunogenic and protective against infection by Bordetella pertussis. The moderate levels of PT production by B. pertussis, however, make it the limiting antigen in the formulation of multicomponent, ac...

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Dades bibliogràfiques

Publicat a:	Appl Environ Microbiol
Autors principals:	Zealey, G R, Loosmore, S M, Yacoob, R K, Cockle, S A, Herbert, A B, Miller, L D, Mackay, N J, Klein, M H
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1992
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1539974/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.58.1.208-214.1992
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