Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.

Nontoxic analogs of pertussis toxin (PT), produced by in vitro mutagenesis of the tox operon, are immunogenic and protective against infection by Bordetella pertussis. The moderate levels of PT production by B. pertussis, however, make it the limiting antigen in the formulation of multicomponent, ac...

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Veröffentlicht in:	Appl Environ Microbiol
Hauptverfasser:	Zealey, G R, Loosmore, S M, Yacoob, R K, Cockle, S A, Herbert, A B, Miller, L D, Mackay, N J, Klein, M H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1539974/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.58.1.208-214.1992
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