Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine.

Pertussis toxin (PT) is an important protective antigen in vaccines against whooping cough, and a genetically detoxified PT analog is the preferred form of the immunogen. Several amino acids of the S1 subunit were identified as functionally critical residues by site-directed mutagenesis, specificall...

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Detaylı Bibliyografya
Asıl Yazarlar: Loosmore, S M, Zealey, G R, Boux, H A, Cockle, S A, Radika, K, Fahim, R E, Zobrist, G J, Yacoob, R K, Chong, P C, Yao, F L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1990
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC313711/
https://ncbi.nlm.nih.gov/pubmed/2228237
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