Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine.

Pertussis toxin (PT) is an important protective antigen in vaccines against whooping cough, and a genetically detoxified PT analog is the preferred form of the immunogen. Several amino acids of the S1 subunit were identified as functionally critical residues by site-directed mutagenesis, specificall...

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Pubblicato in:	Infect Immun
Autori principali:	Loosmore, S M, Zealey, G R, Boux, H A, Cockle, S A, Radika, K, Fahim, R E, Zobrist, G J, Yacoob, R K, Chong, P C, Yao, F L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2228237/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.11.3653-3662.1990
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