Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA

BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only proteins to the hydrophobic groove of antiapoptotic BCL2 proteins. The selectivity of these molecules for BCL2, BCL-X(L), or MCL1 has been established in vitro; whether they inhibit these proteins in cells has n...

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Bibliografische gegevens
Hoofdauteurs: Albershardt, Tina C., Salerni, Bethany L., Soderquist, Ryan S., Bates, Darcy J. P., Pletnev, Alexandre A., Kisselev, Alexei F., Eastman, Alan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137063/
https://ncbi.nlm.nih.gov/pubmed/21628457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255828
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