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IL-2–Controlled Expression of Multiple T Cell Trafficking Genes and Th2 Cytokines in the Regulatory T Cell-Deficient Scurfy Mice: Implication to Multiorgan Inflammation and Control of Skin and Lung Inflammation

Scurfy (Sf) mice bear a mutation in the Foxp3 transcription factor, lack regulatory T cells (Treg), develop multiorgan inflammation, and die prematurely. The major target organs affected are skin, lungs, and liver. Sf mice lacking the Il2 gene (Sf.Il2(−/−)), despite being devoid of Treg, did not dev...

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Detalhes bibliográficos
Main Authors: Sharma, Rahul, Sharma, Poonam R., Kim, Youngchul, Leitinger, Norbert, Lee, Jae K., Fu, Shu Man, Ju, Shyr-Te
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136806/
https://ncbi.nlm.nih.gov/pubmed/21169543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002677
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