A Self-Reactive TCR Drives the Development of Foxp3(+) Regulatory T Cells that Prevent Autoimmune Disease()

Although Foxp3(+) regulatory T (T(reg)) cells are thought to express autoreactive TCRs, it is not clear how individual TCRs influence T(reg) cell development, phenotype, and function in vivo. We have generated TCR transgenic mice (termed SFZ70 mice) using Tcra and Tcrb genes cloned from an autoreact...

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Bibliographic Details
Main Authors: Killebrew, Justin R., Perdue, Nikole, Kwan, Alan, Thornton, Angela M., Shevach, Ethan M., Campbell, Daniel J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136363/
https://ncbi.nlm.nih.gov/pubmed/21690323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004009
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