Activation-induced cytidine deaminase mediates central tolerance in B cells

The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair. These processes are crucial for the ge...

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Detalles Bibliográficos
Main Authors: Kuraoka, Masayuki, Holl, T. Matt, Liao, Dongmei, Womble, Mandy, Cain, Derek W., Reynolds, Alexander E., Kelsoe, Garnett
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136303/
https://ncbi.nlm.nih.gov/pubmed/21700885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102571108
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