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Activation-induced cytidine deaminase mediates central tolerance in B cells
The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair. These processes are crucial for the ge...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136303/ https://ncbi.nlm.nih.gov/pubmed/21700885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102571108 |
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