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Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes
Cell division, membrane rigidity, and strong adhesion to a rigid matrix are all promoted by myosin-II, and so multinucleated cells with distended membranes—typical of megakaryocytes (MKs)—seem predictable for low myosin activity in cells on soft matrices. Paradoxically, myosin mutations lead to defe...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136287/ https://ncbi.nlm.nih.gov/pubmed/21709232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017474108 |
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