Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer–9-AC Conjugate in Rats

PURPOSE: To quantitate and predict colon-specific 9-aminocamptothecin (9-AC) release from the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer–9-AC conjugate and its absorption behavior after oral administration in rats. METHODS: Drug distribution in the gastrointestinal (GI) tract and the plasma...

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Hlavní autoři: Gao, Song-Qi, Sun, Yongen, Kopečková, Pavla, Peterson, C. Matthew, Kopeček, Jindřich
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136142/
https://ncbi.nlm.nih.gov/pubmed/17929146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9465-3
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