A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

Ciliogenesis precedes lineage-determining signaling in skin development. To understand why, we performed shRNA-mediated knockdown of seven intraflagellar-transport-proteins (IFTs), and conditional ablation of Ift-88 and Kif3a during embryogenesis. Both in cultured keratinocytes and embryonic epiderm...

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Bibliografiske detaljer
Main Authors: Ezratty, Ellen, Stokes, Nicole, Chai, Sophia, Shah, Alok, Williams, Scott, Fuchs, Elaine
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135909/
https://ncbi.nlm.nih.gov/pubmed/21703454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.05.030
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