Evaluation of Novel N(1)-Methyl-2-phenylindol-3-ylglyoxylamides as a New Chemotype of 18 kDa Translocator Protein-Selective Ligand Suitable for the Development of Positron Emission Tomography Radioligands

A novel series of N(1)-methyl-(2-phenylindol-3-yl)glyoxylamides 19–31, designed in accordance with our previously reported pharmacophore/topological model, showed high affinity for the 18 kDa translocator protein (TSPO) and paved the way for developing a new radiolabeled probe. Thus ligand 31, N,N-d...

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Hlavní autoři: Pike, Victor W., Taliani, Sabrina, Lohith, Talakad G., Owen, David R.J., Pugliesi, Isabella, Da Pozzo, Eleonora, Hong, Jinsoo, Zoghbi, Sami S., Gunn, Roger N., Parker, Christine A., Rabiner, Eugenii A., Fujita, Masahiro, Innis, Robert B., Martini, Claudia, Da Settimo, Federico
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135721/
https://ncbi.nlm.nih.gov/pubmed/21133364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101230g
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