Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin

BACKGROUND: Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA repair is a potential strategy to enhance cisplatin effectiveness. After cispla...

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Autores principales: Sand-Dejmek, Janna, Adelmant, Guillaume, Sobhian, Bijan, Calkins, Anne S, Marto, Jarrod, Iglehart, Dirk J, Lazaro, Jean-Bernard
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135565/
https://ncbi.nlm.nih.gov/pubmed/21679440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-74
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