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Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.

The role of the single cysteine residue in the activity of the thiol-activated toxin pneumolysin was investigated using oligonucleotide-mediated, site-directed mutagenesis. Three modified toxins in which the cysteine residue was changed to an alanine, a serine, or a glycine residue were purified to...

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Bibliografische gegevens
Hoofdauteurs: Saunders, F K, Mitchell, T J, Walker, J A, Andrew, P W, Boulnois, G J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1989
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC313484/
https://ncbi.nlm.nih.gov/pubmed/2744861
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