Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.

The role of the single cysteine residue in the activity of the thiol-activated toxin pneumolysin was investigated using oligonucleotide-mediated, site-directed mutagenesis. Three modified toxins in which the cysteine residue was changed to an alanine, a serine, or a glycine residue were purified to...

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Bibliografische gegevens

Gepubliceerd in:	Infect Immun
Hoofdauteurs:	Saunders, F K, Mitchell, T J, Walker, J A, Andrew, P W, Boulnois, G J
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1989
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2744861/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.8.2547-2552.1989
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