Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.

The role of the single cysteine residue in the activity of the thiol-activated toxin pneumolysin was investigated using oligonucleotide-mediated, site-directed mutagenesis. Three modified toxins in which the cysteine residue was changed to an alanine, a serine, or a glycine residue were purified to...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Saunders, F K, Mitchell, T J, Walker, J A, Andrew, P W, Boulnois, G J
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1989
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313484/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2744861/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.8.2547-2552.1989
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