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Design, Synthesis, and Validation of a β-Turn Mimetic Library Targeting Protein–Protein and Peptide–Receptor Interactions
The design and synthesis of a β-turn mimetic library as a key component of a small molecule library targeting the major recognition motifs involved in protein–protein interactions is described. Analysis of a geometric characterization of 10,245 β-turns in the protein data bank (PDB) suggested that t...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134394/ https://ncbi.nlm.nih.gov/pubmed/21609016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201878v |
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