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Design, Synthesis, and Validation of a β-Turn Mimetic Library Targeting Protein–Protein and Peptide–Receptor Interactions

The design and synthesis of a β-turn mimetic library as a key component of a small molecule library targeting the major recognition motifs involved in protein–protein interactions is described. Analysis of a geometric characterization of 10,245 β-turns in the protein data bank (PDB) suggested that t...

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Bibliografski detalji
Glavni autori: Whitby, Landon R., Ando, Yoshio, Setola, Vincent, Vogt, Peter K., Roth, Bryan L., Boger, Dale L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134394/
https://ncbi.nlm.nih.gov/pubmed/21609016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201878v
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