Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library

[Image: see text] The evaluation of a comprehensive α-helix mimetic library for binding the gp41 NHR hydrophobic pocket recognizing an intramolecular CHR α-helix provided a detailed depiction of structural features required for binding and led to the discovery of small molecule inhibitors (K(i) 0.6–...

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Main Authors: Whitby, Landon R., Boyle, Kristopher E., Cai, Lifeng, Yu, Xiaoqian, Gochin, Miriam, Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321071/
https://ncbi.nlm.nih.gov/pubmed/22424973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.02.062
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