Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype

Fanconi anemia (FA) is a human genetic disease characterized by chromosome instability, cancer predisposition, and cellular hypersensitivity to DNA crosslinking agents. The FA pathway regulates the repair of DNA crosslinks. A critical step in this pathway is the monoubiquitination and deubiquitinati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kim, Jung Min, Parmar, Kalindi, Huang, Min, Weinstock, David M., Ruit, Carrie Ann, Kutok, Jeffrey L., D’Andrea, Alan D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134285/
https://ncbi.nlm.nih.gov/pubmed/19217432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.01.001
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