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Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences
Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway. This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous recombination. In FA proper repair of ICLs is...
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| Publicado no: | Genes (Basel) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7767525/ https://ncbi.nlm.nih.gov/pubmed/33371494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11121528 |
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