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Dendritic cells from humans with hypomorphic mutations in NEMO have impaired mitogen-activated protein kinase activity
The covalent attachment of lysine 63-linked polyubiquitin to the zinc finger domain of IKBKG/NEMO (also known as IKKγ) is necessary for full activation of NF-κB. Impairments of this biochemical mechanism explain the deleterious effects of hypomorphic NEMO mutations on NF-κB signaling function in hum...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134100/ https://ncbi.nlm.nih.gov/pubmed/21309033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21439 |
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