Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination

Ectodermal dysplasia with immune deficiency (EDI) is caused by alterations in NEMO (nuclear factor [NF]–κB essential modulator). Most genetic mutations are located in exon 10 and affect the C-terminal zinc finger domain. However, the biochemical mechanism by which they cause immune dysfunction remai...

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Autores principales: Temmerman, Stephane T., Ma, Chi A., Borges, Louis, Kubin, Marek, Liu, Shuying, Derry, Jonathan M. J., Jain, Ashish
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2006
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895566/
https://ncbi.nlm.nih.gov/pubmed/16794254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-017210
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