Wird geladen...
Dendritic cells from humans with hypomorphic mutations in NEMO have impaired mitogen-activated protein kinase activity
The covalent attachment of lysine 63-linked polyubiquitin to the zinc finger domain of IKBKG/NEMO (also known as IKKγ) is necessary for full activation of NF-κB. Impairments of this biochemical mechanism explain the deleterious effects of hypomorphic NEMO mutations on NF-κB signaling function in hum...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134100/ https://ncbi.nlm.nih.gov/pubmed/21309033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21439 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|