Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury

Factor H is a regulator of the alternative pathway of complement. Genetic studies have revealed that patients with factor H mutations are at increased risk for several types of renal disease. Pathogenic activation of the alternative pathway in acquired diseases, such as ischemic acute kidney injury,...

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Main Authors: Renner, Brandon, Ferreira, Viviana P., Cortes, Claudio, Goldberg, Ryan, Ljubanovic, Danica, Pangburn, Michael K., Pickering, Matthew C., Tomlinson, Stephen, Holland-Neidermyer, Amanda, Strassheim, Derek, Holers, V. Michael, Thurman, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133686/
https://ncbi.nlm.nih.gov/pubmed/21544060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2011.115
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