A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

Histone methylations are important chromatin marks that regulate gene expression, genomic stability, DNA repair, and genomic imprinting. Histone demethylases are the most recent family of histone-modifying enzymes discovered. Here, we report the characterization of a small-molecule inhibitor of Jumo...

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Main Authors: Luo, Xuelai, Liu, Yongxiang, Kubicek, Stefan, Myllyharju, Johanna, Tumber, Anthony, Ng, Stanley, Che, Ka Hing, Podoll, Jessica, Heightman, Tom D., Oppermann, Udo, Schreiber, Stuart L., Wang, Xiang
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133600/
https://ncbi.nlm.nih.gov/pubmed/21585201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201597b
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