Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics

OBJECTIVES: The aim of this study was to comprehensively evaluate the antibacterial activity and MurE inhibition of a set of N-methyl-2-alkenyl-4-quinolones found to inhibit the growth of fast-growing mycobacteria. METHODS: Using the spot culture growth inhibition assay, MICs were determined for Myc...

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Detaylı Bibliyografya
Asıl Yazarlar: Guzman, Juan David, Wube, Abraham, Evangelopoulos, Dimitrios, Gupta, Antima, Hüfner, Antje, Basavannacharya, Chandrakala, Rahman, Md. Mukhleshur, Thomaschitz, Christina, Bauer, Rudolf, McHugh, Timothy Daniel, Nobeli, Irene, Prieto, Jose M., Gibbons, Simon, Bucar, Franz, Bhakta, Sanjib
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133487/
https://ncbi.nlm.nih.gov/pubmed/21622974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr203
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