Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics

OBJECTIVES: The aim of this study was to comprehensively evaluate the antibacterial activity and MurE inhibition of a set of N-methyl-2-alkenyl-4-quinolones found to inhibit the growth of fast-growing mycobacteria. METHODS: Using the spot culture growth inhibition assay, MICs were determined for Myc...

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Dettagli Bibliografici
Autori principali: Guzman, Juan David, Wube, Abraham, Evangelopoulos, Dimitrios, Gupta, Antima, Hüfner, Antje, Basavannacharya, Chandrakala, Rahman, Md. Mukhleshur, Thomaschitz, Christina, Bauer, Rudolf, McHugh, Timothy Daniel, Nobeli, Irene, Prieto, Jose M., Gibbons, Simon, Bucar, Franz, Bhakta, Sanjib
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133487/
https://ncbi.nlm.nih.gov/pubmed/21622974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr203
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